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(“PMI”) (NYSE / Euronext Paris: PM) on Dec. 5 submitted a Modified Risk Tobacco Product (MRTP) application for its electronically heated tobacco product with the U.S. Food and Drug Administration’s (FDA) Center for Tobacco Products. This is consistent with the company’s stated goal of submitting its MRTP application in 2016. PMI anticipates the FDA taking a minimum of 60 days to complete an administrative review to determine whether to accept the application for substantive review. Philip Morris International Inc. (PMI) is the world’s leading international tobacco company, with six of the world's top 15 international brands and products sold in more than 180 markets. In addition to the manufacture and sale of cigarettes, including Marlboro, the number one global cigarette brand, and other tobacco products, PMI is engaged in the development and commercialization of Reduced-Risk Products (“RRPs”). RRPs is the term PMI uses to refer to products with the potential to reduce individual risk and population harm in comparison to smoking cigarettes. Through multidisciplinary capabilities in product development, state-of-the-art facilities, and industry-leading scientific substantiation, PMI aims to provide an RRP portfolio that meets a broad spectrum of adult smoker preferences and rigorous regulatory requirements.

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Drug and Alcohol Dependence In 2009, the FDA required a black box warning (BBW) on bupropion and varenicline, the two commonly prescribed smoking cessation agents due to reports of adverse neuropsychiatric events. We investigated if there was a decline in use of bupropion and varenicline after the BBW by comparing the percent using these medications before and after BBW. We conducted a retrospective observational study using data from the Medical Expenditure Panel Survey from 2007 to 2014. The study sample consisted of adult smokers, who were advised by their physicians to quit smoking. We divided the time period into “pre-warning”, “post-warning: immediate”, and “post-warning: late.” Unadjusted analysis using chi-square tests and adjusted analyses using logistic regressions were conducted to evaluate the change in bupropion and varenicline use before and after the BBW. Secondary analyses using piecewise regression were also conducted. On an average, 49.04% of smokers were advised by their physicians to quit smoking. We observed a statistically significant decline in varenicline use from 22.1% in year 2007 to 9.23% in 2014 (p value < 0.001). In the logistic (Adjusted Odds Ratio = 0.36, 95% CI = 0.22–0.58) and piecewise regressions (Odds Ratio = 0.64, 95% CI = 0.41–0.99) smokers who were advised to quit smoking by their physicians were less likely to use varenicline in the immediate post-BBW period as compared to pre-BBW period.

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Smoke Stik USA Electronic CigarettesSo, I hope all of this has helped someone in their quest for a safer alternative to analog cigs. I was a 1pad smoker for over 10 years…and I don't ever want to go back! If you really enjoy the act of smoking, but tired of the nasty inside and outside of your body, it's worth the try to switch to an e-cig…Read all reviews and research all of your options. It's soooo worth it.So, I'll start with the good news. The flavors are impressive. There are only six varieties on offer but from the sounds of them, they're a little something different from the norm. With Bombshell, Fresh Mint, Rodeo Drive, Passion Fruit, Strawberry Champagne and Arctic Mint, I was super excited for the Passion Fruit and Strawberry Champagne ones. Don't we all love a little something sweet?So, let's say that we put together our own starter kit consisting of the ONE kit SmokeTip has to offer at $39.95, plus two large batteries at $24.95 each, a car charger and USB cigarette and the total currently stands at $128.75. Add the portable charging case at $147.95, and you might as well have just bought one of the more expensive kits from the likes of Green Smoke or V2 Cigs.So, why are 'cigalikes' so popular? Well, it really comes down to a couple of different things. For a start, they closely replicate the same design as the tobacco cigarettes that vapers are leaving behind. When making the switch, something which closely resembles and performs like a cigarette is less intimidating and far easier to get to grips with than more advanced devices.Society is structured to discourage the growth and development of our minds. It's expected that we will grow to fit a pre defined mould. We're expected to learn more and more about less and less as we grow older in a world which expects and encourages speciality. Why? It is said we only use a miserable 10% of our brains. If this is true.

CMO Today’s Alexandra Bruell reports: Anheuser-Busch InBev has consolidated its global media account with four agencies, down from eight. Dentsu Aegis Network wins the large U.S. account from incumbent Mediacom, which is owned by WPP. Omnicom, WPP and Publicis media agencies will support various international markets. Lucas Herscovici, a global marketing executive at the beer giant, said the consolidation was designed to “reduce complexity.” Usually, that’s code for cost savings, but Mr. Herscovici insisted that wasn’t the motivation. Still, he admitted, “In every pitch of this nature when you’re involving over 50 countries [with] spends in the hundreds of millions of dollars, and when there’s competition across agencies, obviously savings are achieved.” Winning shops should feel good about adding business at a time when most holding companies are reporting subpar growth. They shouldn’t bank on major profits from programmatic fees. The company already handles programmatic buying in-house and plans to expand the model globally, Mr. Herscovici said.

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