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Drug and Alcohol Dependence Subcortical white matter (WM), thalamus, cerebellar cortex, and corpus callosum were most affected. Higher cigarette pack-years related to smaller volumes in several subcortical regions. Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. Non-smokers (n = 43) and smokers (n = 40), 22–70 years of age, completed a 4 T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions. In smokers, higher pack-years were associated with smaller volumes of the bilateral amygdala, nucleus accumbens, total corpus callosum and subcortical WM. Results provide novel evidence that chronic smoking in adults is associated with accelerated age-related volume loss in subcortical WM and GM nuclei.

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Good morning. Vanity Fair’s New Establishment Summit kicks off today, featuring some of the biggest names in the media business, and it looks as if there will be at least one news item. As Business Insider’s Alex Heath sleuthed, Snap CEO Evan Spiegel is likely to be announcing a partnership with artist Jeff Koons to showcase his famous art installations as augmented reality 3-D objects within the Snapchat app. The issue of relying on automation raised its head again for both Google and Facebook on Monday in the aftermath of the deadly Las Vegas shooting. As CNN reported, for a few hours, Google’s “Top Stories” section featured a 4chan message-board discussion that wrongly identified the shooter. Facebook’s “Crisis Response” page surfaced a now-deleted story from far-right website the Gateway Pundit that also blamed the wrong person for the massacre. Both Google and Facebook removed the posts, but the screenshots had already been captured, and questions are being raised again about how much responsibility the two companies are taking upon themselves to prevent the spread of misinformation. “ Google and Facebook Failed Us ,” read the Atlantic’s headline. If companies like Google and Facebook rely too much on human intervention, they face accusations of bias, and it’s a slippery slope to being considered as media owners rather than the passive platforms they would prefer to be. But, as we keep seeing time and time again—with brand safety, fake news, anti-Semitic ad targeting—relying on algorithms alone is a clearly flawed approach.

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